2008 Jul; 48(1):322-35. Proc Natl Acad Sci U S A. Hepatology. 1999 Apr 15; 162(8):4447-54. 2014 Mar 07; 289(10):7082-7091. 2006 Apr; 43(4):872-8. 2005 Jul 29; 280(30):27879-87. Hepatology. To return to the graph. New functions for the aryl hydrocarbon receptor. Am J Physiol. FASEB J. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Cloning of murine ferrochelatase. 2010 Mar; 51(3):1027-36. 2001 Jul 01; 167(1):173-80. Nat Rev Gastroenterol Hepatol. Curr Opin Gastroenterol. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Proc Natl Acad Sci U S A. N Engl J Med. Mol Cell Biol. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. 2013 Mar; 37(6):630-9. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. 2007 Apr-Jun; 6(2):83-8. Genomics of liver fibrosis and cirrhosis. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. 2008 Feb; 47(2):677-85. 2008 Jul; 255(7):993-1000. Semin Liver Dis. 2020; 11:370. 2000 Apr 21; 275(16):11814-23. Cell. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. Double-strand gap repair results in homologous recombination in mouse L cells. J Cell Biol. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. 2000 Jul; 279(1):G100-6. Luedde T, Rodriguez ME, Tacke F, Xiong Y. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Alteration of interferon-a/ receptors in chronic hepatitis B patients. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 2010 Feb 25; 3:39-47. Science. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. Gastroenterology. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. Nature. Front Physiol. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. Nucleic Acids Res. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. Cell Metab. 1993 Jan; 264(1 Pt 1):G95-103. 2023 Jan 17; 1-6. Hepatology. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Interactions between the intestinal microbiome and liver diseases. Recent advancement of molecular mechanisms of liver fibrosis. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. HBO Special recorded in Las 2012 Dec; 56(6):2316-27. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? The enzymatic defect in variegate prophyria. Proc Am Thorac Soc. AIDS. FASEB J. 2005 May; 41(5):1046-55. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. 2015 Mar; 29(3):1043-55. Transplantation. 2004 Dec; 127(6):1659. 2011 Oct; 89(10):997-1013. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Neurogastroenterol Motil. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. Hepatology. Hepatology. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK. 2011 Jan; 53(1):96-105. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. 1995; 255:342-59. DNA Cell Biol. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. Gut. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B. Hepatology. Nucleic Acids Symp Ser. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. 2004 Apr; 18(6):720-2. 1998 Sep; 13(S1):S93-S95. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. J Gastroenterol Hepatol. 2019 09; 71(3):573-585. Gastroenterology. Am J Physiol Gastrointest Liver Physiol. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. Am J Physiol. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Mol Ther Nucleic Acids. Alcohol Clin Exp Res. PLoS One. Hepatology. 2001 Jun 01; 166(11):6812-9. Am J Physiol Gastrointest Liver Physiol. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Nat Rev Gastroenterol Hepatol. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Cell Death Differ. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. J Theor Biol. 2019 11 05; 30(5):850-852. J Clin Gastroenterol. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Alzheimer's disease: the vascular connection. 2021 07 20; 118(29). Joint statement on missions and submissions of papers to AGA journals. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. 2000 Nov 01; 28(21):4306-16. 2010 Jan; 30(1):31-41. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. 2004 Feb; 126(2):529-40. 2007 Dec; 52(12):3404-15. Alcohol. Hum Gene Ther. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Am J Physiol. Biochem Biophys Res Commun. Nat Commun. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER J Gastroenterol. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. Trans Am Clin Climatol Assoc. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. 2006 Jul; 131(1):272-5. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. Gastroenterology. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. Hepatobiliary Surg Nutr. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics 2022 Apr 04. 1999; 8(3):151-63. 2013 Dec; 11(12):1636-45.e1-3. J Clin Invest. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. Hepatology. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Gastroenterology. Is it the end of the line for the EMT? WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. 2019 10; 68(10):1884-1892. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. 2011 Dec; 17(4):251-7. 1989 Feb 16; 337(6208):661-3. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T. Intestinal Virome in Patients With Alcoholic Hepatitis. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. 2005 Sep-Oct; 7(9-10):1346-55. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. WebView David Brenners profile on LinkedIn, the worlds largest professional community. Stroke. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. See more options in the Advanced Search tab. J Hepatol. 2004 Aug 15; 78(3):324-32. Modulation of constitutive collagen gene expression by lipid peroxidation. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. Cell Metab. Dig Dis. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Gastroenterol. Stroke. J Clin Invest. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Am J Hum Genet. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. 2015 Nov-Dec; 49 Suppl 1:S25-7. 2004 Jan; 2(1):9-13. 2020; 4(5):561-580. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Alcohol Clin Exp Res. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Mechanisms of fibrogenesis. 2000 Jan; 118(1):90-100. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. J Biol Chem. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Molecular mechanisms of alcohol-induced hepatic fibrosis. 2001 Jul 10; 104(2):221-6. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. Biochem Biophys Res Commun. J Hepatobiliary Pancreat Sci. Proc Natl Acad Sci U S A. J Immunol. What goes up must come down: the emerging role of microRNA in fibrosis. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Exp Neurol. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. 1987 Dec 25; 262(36):17690-5. Transplantation. Hepatology. 1998 04; 274(4):G669-76. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. 2017 12; 1(10):1043-1057. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. 2003 Jul; 39(1):38-46. 2019 02 04; 216(2):267-278. Mol Metab. 2015 Dec; 149(7):1784-93. 2013 02 15; 177(4):333-42. J Biol Chem. J Clin Invest. 2006 Apr; 290(4):G583-9. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. 2020 01; 245(2):96-108. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. 1994 Jul 29; 269(30):19203-6. Gut. He will assume his new role effective September 14. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. 2012 Nov; 13(11):1072-82. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. 1993 Jan; 17(1):164-6. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. 2004 Nov; 40(5):1106-15. Nat Commun. 2020 12; 72(6):2182-2196. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. People who share similar concepts with this person. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Proc Natl Acad Sci U S A. Hepatology. The recombination and integration of DNAs introduced into mouse L cells. J Biol Chem. 2003 Oct; 23(5):386-96. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. 1992 Feb 28; 183(1):184-92. J Immunol. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Hepatology. 2000 Dec; 32(6):1272-9. 2001 Jan; 280(1):G139-48. Gastroenterology. 2020; 144(8):400-412. 2002 Aug; 36(2):315-25. 1999 Mar; 31(2):173-9. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Hepatology. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. People in Profiles who have published with this person. Recorded in Las 2012 Dec ; 56 ( 6 ):2316-27 Juma B, Stefanovic L Schnabl. In fibrosis nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits 30 5. 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